Introduction to Survival Analysis
DOI:
https://doi.org/10.52787/agl.v52i1.164Keywords:
survival analysis, methodologyAbstract
What is Survival Analysis?
In many clinical situations, we are interested not only in studying whether an event occurs, but also in deter-mining at what point it take place during the follow-up.
Survival analysis is a set of statistical procedures for data analysis in which the outcome variable is the time until an event occurs.
What Is It for?
The first applications of this analysis studied the time from the start of treatment to death, hence the name “survival”. Subsequently, it was extended to other situations of clinical interest (time to readmission, treatment abandonment, return to work after surgery, etc.), so that a more appropriate name is time-to-event analysis.
The objectives of survival analysis are: a) to estimate and interpret survival, b) to compare survival between different groups, and c) to evaluate the relationship of different explanatory variables with survival.1
References
- 1. Kleinbaum DG, Klein M. Survival Analysis: A Self-Learning Text. New York: Springer; 2012.
- 2. Bewick V, Cheek L, Ball J. Statistics review 12: Survival analysis. Critical Care 2004;8:389-395.
- 3. Tolles J, Lewis RJ. Time-to-Event Analysis. JAMA 2016;315(10):1046-1047.
- 4. Stensrud MJ, Hernán MA. Why Test for Proportional Hazards?. JAMA 2020;323(14):1401-1402.
- 5. Uno H, Claggett B, Tian L, et al. Moving Beyond the Hazard Ratio in Quantifying the Between-Group Difference in Survival Analysis. J Clin Oncol 2014;32:2380-2385.
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