Benign Lesions Located in the Liver from an Imaging Perspective

Authors

DOI:

https://doi.org/10.52787/agl.v53i1.308

Keywords:

Benign hepatic focal lesions, hepatic hemangioma, focal nodular hyperplasia, hepatocellular adenoma, imaging, computed tomography, magnetic resonance

Abstract

The vast majority of benign focal liver lesions are incidentally discovered in imaging exams performed in a variety of clinical scenarios. Such detection has increased as a result of technological progress and in the increasingly frequent use of different imaging methods. Focal imaging findings pose diagnostic dilemmas, and therefore, the consequent challenge of how to treat them. This review will analyze the most frequent benign focal liver lesions and their appearance on different imaging techniques. Moreover, emphasis will be placed on the characteristics that help to narrow the differential diagnosis and eventually suggest a specific diagnosis.

References

-1. Stark DD, Felder RC, Wittenberg J, Saini S, Butch RJ, White ME, et al. Magnetic resonance imaging of cavernous hemangioma of the liver: tissue specific characterization. AJR Am J Roentgenol 1985;145:213-222.

-2. Doo KW, Lee CH, Choi JW, Lee J, Kim KA, Park CM. ‘‘Pseudo washout” sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor. AJR Am J Roentgenol 2009;193:W490-W496.

-3. Jordan D. LeGout, Candice W. Bolan, Andrew W. Bowman, Melanie P. Caserta, Frank K. Chen, Kelly L. Cox, Rupan Sanyal, Beau B. Toskich, Jason T. Lewis, and Lauren F. Alexander. Focal nodular hyperplasia and focal nodular hyperplasia-like lesions. RadioGraphics 2022;42:4,1043-1061.

-4. Brancatelli G, Federle MP, Grazioli L, Blachar A, Peterson MS, Thaete L. Focal nodular hyperplasia: CT findings with emphasis on multiphasic helical CT in 78 patients. Radiology 2001;219:61-68.

-5. Vilgrain V, Flejou JF, Arrive L, Belghiti J, Najmark D, Menu Y, et al. Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients. Radiology 1992;184:699-703.

-6. Grieser C, Steffen IG, Seehofer D, Kramme IB, Uktolseya R, ScheurigMuenkler C, et al. Histopathologically confirmed focal nodular hyperplasia of the liver: gadoxetic acid-enhanced MRI characteristics. Magn Reson Imaging 2013;31:755-760.

-7. Suh CH, Kim KW, Kim GY, Shin YM, Kim PN, Park SH. The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis. Eur Radiol 2015;25:950-960.

-8. EASL Clinical Practice Guidelines on the management of benign liver tumours. Journal of Hepatology, Volume 65, Issue2, 386-398.

Zucman-Rossi J, Jeannot E, Nhieu JT, Scoazec JY, Guettier C, Rebouissou S, et al. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 2006;43:515-524.

-10. Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, et al. Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. Gastroenterology 2016.

-11. Aalten SMv, Thomeer MGJ, Terkivatan T, et al. Hepatocellular adenomas: Correlation of MR imaging findings with pathologic subtype classification. Radiology 2011;261:172-181.

-12. Zulfiqar M, Sirlin CB, Yoneda N, et al. Hepatocellular adenomas: understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach. J Magn Reson Imaging 2020;51:1630-1640.

-13. Glockner JF, Lee CU, Mounajjed T. Inflammatory hepatic adenomas characterization with hepatobiliary MRI contraste atents. Magn Reson imaging 2018;47:103-110.

-14. Zulfiqar M, Sirlin CB, Yoneda N, et al. Hepatocellular adenomas: understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach. J Magn Reson Imaging 2020;51:1630-1640.

-15. Kengo Yoshimitsu, Hiroshi Honda, Toshiro Kuroiwa, Hiroyuki Irie, Hitoshi Aibe, Kenji Shinozaki, and Kouji Masuda. Unusual Hemodynamics and Pseudolesions of the Noncirrhotic Liver at CT. RadioGraphics 2001,21:suppl_1,S81-S96

-16. Wynnson W. Tom, Benjamin M. Yeh, Jonathan C. Cheng, Aliya Qayyum, Bonnie Joe, and Fergus V. Coakley. Hepatic Pseudotumor Due To Nodular Fatty Sparing: The Diagnostic Role of Opposed-Phase MRI.A merican Journal of Roentgenology,2004;183:3,721-724.

Published

2023-03-30

How to Cite

Volpacchio, M. (2023). Benign Lesions Located in the Liver from an Imaging Perspective. Acta Gastroenterológica Latinoamericana, 53(1), 18–27. https://doi.org/10.52787/agl.v53i1.308