The Future of Clinical Trials

Abstract

Clinical trials represent the highest level of evidence for medical decision-making, as indicated in clinical guidelines under the class I recommendation. However, these studies present limitations, such as the time and costs required, difficulty obtaining samples from some populations, and ethical barriers. A clear definition of prognostic or predictive biomarkers and well-established endpoints are essential to accelerate the development of new drugs. In addition, personnel limitations can hinder the progress of clinical trials.