Pancreatic Atypical Neurofibromatous Neoplasm with Uncertain Biological Potential (ANNUBP) Mimicking a Solid Pseudopapillary Tumor Pancreatic ANNUBP
DOI:
https://doi.org/10.52787/agl.v55i4.481Keywords:
Atypical neurofibromatous neoplasms of uncertain biological potential, pancreatic tumor, pancreaticoduodenectomy, neurofibromatosis type 1Abstract
Atypical neurofibromatous neoplasms of uncertain biological potential have recently been added as a subset of lesions with the potential to transform into malignant peripheral nerve sheath tumors in patients with neurofibromatosis type 1. Only a few cases of atypical neurofibromatous neoplasms of uncertain biological potential have been reported in the literature. Here, we present the first case of this type of neoplasm located in the pancreas in a 30-year-old woman with neurofibromatosis type 1. The mass was discovered incidentally on imaging studies. Computed tomography and magnetic resonance imaging showed a 3 × 2 cm solid-cystic mass in the head of the pancreas, suggestive of a solid pseudopapillary tumor. Following an inconclusive endoscopic ultrasound-guided biopsy, a pancreaticoduodenectomy was performed. The patient had an uneventful postoperative recovery. Histopathological and immunohistochemical analysis confirmed the diagnosis of atypical neurofibromatous neoplasms of uncertain biological potential. To our knowledge, this is the first report of this type of tumor located in the pancreas. These lesions are often difficult to differentiate from other solid and solid-cystic pancreatic tumors based on imaging studies alone. Imaging techniques such as magnetic resonance imaging and positron emission tomography, together with computed tomography, combined with histopathology and a history of neurofibromatosis type 1, are essential for an accurate diagnosis. Current treatment consists of radical surgical removal of the tumor due to the risk of malignant transformation. This case highlights the importance of considering atypical neurofibromatous neoplasms of uncertain biological potential as a differential diagnosis in patients with neurofibromatosis type 1 presenting with a pancreatic mass, and further studies are needed to improve preoperative diagnostic strategies and evaluate long-term prognosis after surgical resection.
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