Primer consenso centroamericano y del Caribe del síndrome de intestino irritable
DOI:
https://doi.org/10.52787/agl.v53i2.272Palabras clave:
Síndrome de intestino irritable, diarrea, estreñimiento, consenso, criterios diagnósticos, tratamiento, CentroaméricaResumen
El síndrome de intestino irritable sigue siendo uno de los trastornos gastrointestinales más comunes observados por los médicos, tanto en la atención primaria como en la secundaria. Se han logrado avances significativos en la comprensión de su compleja fisiopatología, lo que resulta en su reclasificación como un trastorno de la interacción intestino-cerebro, en lugar de un trastorno gastrointestinal funcional. La condición afecta a entre el 5% y el 10% de la población y, en la mayoría de los casos, se caracteriza por tener una evolución con recaídas y remisiones. El diagnóstico se puede hacer sobre la base de la historia clínica con un uso limitado y juicioso de las investigaciones, a menos que se presenten síntomas de alarma, como pérdida de peso o sangrado rectal, o que haya antecedentes familiares de enfermedad inflamatoria intestinal o enfermedad celíaca. Los pilares del tratamiento incluyen la educación del paciente sobre la afección, los cambios en la dieta, la fibra soluble y los medicamentos antiespasmódicos. Otros tratamientos tienden a estar reservados para personas con síntomas refractarios e incluyen neuromoduladores centrales, secretagogos intestinales, medicamentos que actúan sobre los receptores opioides o 5-hidroxitriptamina o serotonina (5-HT), o antibióticos mínimamente absorbidos (todos los cuales se seleccionan de acuerdo con el hábito intestinal predominante), así como terapias psicológicas. Este consenso es el resultado del trabajo en conjunto de representantes de la Asociación Centroamericana y del Caribe de Gastroenterología, desarrollado de forma virtual, con el objetivo de presentar una serie de recomendaciones adaptadas a la realidad de la región y que sirvan de referencia en la práctica clínica.
Citas
-1. Berry SK, Brenner DM, Cash BD, Chang L, Chey WD, Deutsch JK, et al. Irritable Bowel Syndrome. An Issue of Gastroenterology Clinics of North America. En: Chey WD, Buchman A, editors. Gastroenterology Clinics of North America [Internet]. Elsevier; 2021. Pp. 487-713. Disponible en: www.us.elsevierhealth.com/irritable-bowel-syndrome-an-issue-of-gastroenterology-clinics-ofnorth-america-9780323809283.html
-2. Sperber AD, Bangdiwala SI, Drossman DA, Ghoshal UC, Simren M, Tack J, et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders. Results of Rome Foundation Global Study. Gastroenterology [Internet]. 2021;160(1):99-114. Disponible en: https://www.sciencedirect.com/science/article/pii/S001650852030487X
-3. Oka P, Parr H, Barberio B, Black CJ, Savarino E V., Ford AC. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol [Internet]. 2020;5(10):908-17. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S246812532030217X
-4. Weaver KR, Melkus GDE, Henderson WA. Irritable bowel syndrome: A review. Am J Nurs [Internet]. 2017;117(6):48-55. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453305/
-5. Spiller RC. Hidden Dangers of Antibiotic Use: Increased Gut Permeability Mediated by Increased Pancreatic Proteases Reaching the Colon. Cell Mol Gastroenterol Hepatol [Internet]. 2018;6(3):347-348.e1. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30182044/
-6. Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu K V., Bastiaanssen TFS, Boehme M, et al. The microbiota-gut-brain axis. Physiol Rev [Internet]. 2019;99(4):1877-2013. Disponible en: www.prv.org
-7. Pittayanon R, Lau JT, Yuan Y, Leontiadis GI, Tse F, Surette M, et al. Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review. Gastroenterology [Internet]. 2019;157(1):97-108. Disponible en: https://doi.org/10.1053/j.gastro.2019.03.049
-8. Drossman DA, Hasler WL. Rome IV - Functional GI disorders: Disorders of gut-brain interaction. Gastroenterology [Internet]. 2016;150(6):1257-61. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27147121/
-9. Fink A, Kosecoff J, Chassin M, Brook RH. Consensus methods: Characteristics and guidelines for use. Am J Public Health [Internet]. 1984;74(9):979-83. Disponible en: https://pubmed.ncbi.nlm.nih.gov/6380323/
-10. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ [Internet]. 2008;336(7650):924-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18436948/
-11. Aguilar-Paiz L, Quintero-Samudio I, Santana-Vargas D, Suazo-Barahona J, Alfaro-Murillo O, Galdámez J, et al. Tu1340: DISORDERS OF GUT-BRAIN INTERACTION (DGBI) IN CENTRAL AMERICA (CA): A ROME IV INTERNET-BASED EPIDEMIOLOGICAL STUDY. AGA ABSTRACTS. Gastroenterology [Internet]. 2022;162(7):S-923. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0016508522621930
-12. Sebastián Domingo JJ. Los nuevos criterios Roma (IV) de los trastornos funcionales digestivos en la práctica clínica. Med Clin (Barc) [Internet]. 2017;148(10):464-8. Disponible en: http://dx.doi.org/10.1016/j.medcli.2016.12.020
-13. Spiller R, Garsed K. Postinfectious Irritable Bowel Syndrome. Gastroenterology. 2009;136(6):1979-88.
-14. Thabane M, Kottachchi DT, Marshall JK. Systematic review and meta-analysis: The incidence and prognosis of post-infectious irritable bowel syndrome. Aliment Pharmacol Ther. 2007;26(4):535-44.
-15. Porter CK, Gormley R, Tribble DR, Cash BD, Riddle MS. The incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population. Am J Gastroenterol [Internet]. 2011;106(1):130-8. Disponible en: https://journals.lww.com/ajg/Abstract/2011/01000/The_Incidence_and_Gastrointestinal_Infectious_Risk.21.aspx
-16. Lacy BE, Mearin F, Chang L, Chey WD, Lembo AJ, Simren M, et al. Bowel disorders. Gastroenterology [Internet]. 2016;150(6):1393-1407.e5. Disponible en: http://www.gastrojournal.org/article/S0016508516002225/fulltext
-17. Chitkara DK, Van Tilburg MAL, Blois-Martin N, Whitehead WE. Early life risk factors that contribute to irritable bowel syndrome in adults: A systematic review [Internet]. Am J Gastroenterol. 2008;103:765-74. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18177446/
-18. Sanger GJ, Chang L, Bountra C, Houghton LA. Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders. Therap Adv Gastroenterol [Internet]. 2010;3(5):291-305. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21180610/
-19. Camilleri M, McKinzie S, Busciglio I, Low PA, Sweetser S, Burton D, et al. Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome. Clin Gastroenterol Hepatol [Internet]. 2008;6(7):772-81. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18456567/
-20. Simrén M, Törnblom H, Palsson OS, Van Oudenhove L, Whitehead WE, Tack J. Cumulative Effects of Psychologic Distress, Visceral Hypersensitivity, and Abnormal Transit on Patient-reported Outcomes in Irritable Bowel Syndrome. Gastroenterology [Internet]. 2019;157(2):391-402.e2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31022401/
-21. Törnblom H, Van Oudenhove L, Sadik R, Abrahamsson H, Tack J, Simrén M. Colonic transit time and IBS symptoms: What’s the link? Am J Gastroenterol [Internet]. 2012;107(5):754-60. Disponible en: https://journals.lww.com/ajg/Fulltext/2012/05000/Colonic_Transit_Time_and_IBS_Symptoms_What_s_the.19.aspx
-22. Agrawal A, Houghton LA, Reilly B, Morris J, Whorwell PJ. Bloating and distension in irritable bowel syndrome: The role of gastrointestinal transit. Am J Gastroenterol [Internet]. 2009;104(8):1998-2004. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19491831/
-23. Houghton LA, Atkinson W, Lockhart S, Fell C, Whorwell PJ, Keevil B. Sigmoid-colonic motility in health and irritable bowel syndrome: A role for 5-hydroxytryptamine. Neurogastroenterol Motil [Internet]. 2007;19(9):724-31. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17539895/
-24. Atkinson W, Lockhart S, Whorwell PJ, Keevil B, Houghton LA. Altered 5-hydroxytryptamine signaling in patients with constipation-and diarrhea-predominant irritable bowel syndrome. Gastroenterology [Internet]. 2006;130(1):34-43. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16401466/
-25. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut [Internet]. 2000;47(6):804-11. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11076879/
-26. Dunlop SP, Hebden J, Campbell E, Naesdal J, Olbe L, Perkins AC, et al. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol [Internet]. 2006;101(6):1288-94. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16771951/
-27. Zhou QQ, Zhang B, Nicholas Verne G. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain [Internet]. 2009;146(1-2):41-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19595511/
-28. Piche T. Tight junctions and IBS - the link between epithelial permeability, low-grade inflammation, and symptom generation [Internet]. Neurogastroenterol Motil. 2014;26:296-302. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24548256/
-29. Piche T, Barbara G, Aubert P, Des Varannes SB, Dainese R, Nano JL, et al. Impaired Intestinal barrier integrity in the colon of patients with irritable bowel syndrome: Involvement of soluble mediators. Gut [Internet]. 2009];58(2):196-201. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18824556/
-30. Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, et al. Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function. Am J Gastroenterol [Internet]. 2017;112(6):913-23. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28323272/
-31. Bhattarai Y, Muniz Pedrogo DA, Kashyap PC. Irritable bowel syndrome: A gut microbiota-related disorder? Am J Physiol - Gastrointest Liver Physiol [Internet]. 2016;312(1):G52-62. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27881403/
-32. Grover M, Kanazawa M, Palsson OS, Chitkara DK, Gangarosa LM, Drossman DA, et al. Small intestinal bacterial overgrowth in irritable bowel syndrome: Association with colon motility, bowel symptoms, and psychological distress. Neurogastroenterol Motil [Internet]. 2008;20(9):998-1008. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18482250/
-33. Barba E, Burri E, Accarino A, Cisternas D, Quiroga S, Monclus E, et al. Abdominothoracic mechanisms of functional abdominal distension and correction by biofeedback. Gastroenterology [Internet]. 2015;148(4):732-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25500424/
-34. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature [Internet]. 2014;505(7484):559-63. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24336217/
-35. Koloski NA, Jones M, Weltman M, Kalantar J, Bone C, Gowryshankar A, et al. Identification of early environmental risk factors for irritable bowel syndrome and dyspepsia. Neurogastroenterol Motil [Internet]. 2015;27(9):1317-25. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26202154/
-36. Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera N V, et al. Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts. Gut [Internet]. 2015;64(11):1774-82. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25248455/
-37. Levy RL, Jones KR, Whitehead WE, Feld SI, Talley NJ, Corey LA. Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology. Gastroenterology [Internet]. 2001;121(4):799-804. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11606493/
-38. Lacy BE, Chey WD, Lembo AJ. New and Emerging Treatment Options for Irritable Bowel Syndrome. Gastroenterol Hepatol (NY) [Internet]. 2015;11(4 Suppl 2):1-19. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612133/
-39. Goldstein RS, Cash BD. Making a Confident Diagnosis of Irritable Bowel Syndrome. Gastroenterol Clin North Am [Internet]. 2021;50(3):547-63. Disponible en: http://www.gastro.theclinics.com/article/S0889855321002752/fulltext
-40. Menees SB, Powell C, Kurlander J, Goel A, Chey WD. A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS. Am J Gastroenterol [Internet]. 2015;110(3):444-54. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25732419/
-41. Lacy BE, Pimentel M, Brenner DM, Chey WD, Keefer LA, Long MD, et al. ACG Clinical Guideline: Management of Irritable Bowel Syndrome. Am J Gastroenterol [Internet]. 2021;116(1):17-44. Disponible en: https://journals.lww.com/ajg/Fulltext/2021/01000/ACG_Clinical_Guideline__Management_of_Irritable.11.aspx
-42. Carmona-Sánchez R. La detección y tratamiento del hipotiroidismo subclínico en pacientes con síndrome de intestino irritable. ¿Modifica el uso de recursos de salud? Rev Gastroenterol México [Internet]. 2007;72(3):222-6. Disponible en: http://www.revistagastroenterologiamexico.org//es-la-deteccion-tratamiento-del-hipotiroidismo-articulo-X0375090607232321
-43. Irvine AJ, Chey WD, Ford AC. Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis. Am J Gastroenterol [Internet]. 2017;112(1):65-76. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27753436/
-44. Lewis NR, Scott BB. Meta-analysis: Deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther [Internet]. 2010;31(1):73-81. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19664074/
-45. Van Der Windt DAWM, Jellema P, Mulder CJ, Kneepkens CMF, Van Der Horst HE. Diagnostic testing for celiac disease among patients with abdominal symptoms: A systematic review [Internet]. JAMA. 2010;303:1738-46. Disponible en: https://pubmed.ncbi.nlm.nih.gov/20442390/
-46. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: Time for a standardized report scheme for pathologists [Internet]. Eur J Gastroenterol Hepatol. 1999:11:1185-94. Disponible en: https://pubmed.ncbi.nlm.nih.gov/10524652/
-47. Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol [Internet]. 2013;108(5):656-76. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23609613/
-48. Slattery SA, Niaz O, Aziz Q, Ford AC, Farmer AD. Systematic review with meta-analysis: The prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea [Internet]. Aliment Pharmacol Ther. 2015;42:3-11. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25913530/
-49. Barkun A, Love J, Gould M, Pluta H, Hillary Steinhart A. Bile acid malabsorption in chronic diarrhea: Pathophysiology and treatment [Internet]. Can J Gastroenterol. 2013;27:653-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24199211/
-50. Carrasco-Labra A, Lytvyn L, Falck-Ytter Y, Surawicz CM, Chey WD. AGA Technical Review on the Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). Gastroenterology [Internet]. 2019;157(3):859-80. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31351880/
-51. Vijayvargiya P, Camilleri M, Shin A, Saenger A. Methods for diagnosis of bile acid malabsorption in clinical practice. Clin Gastroenterol Hepatol. 2013;11(10):1232-9.
-52. Pimentel M, Morales W, Rezaie A, Marsh E, Lembo A, Mirocha J, et al. Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects. PLoS One [Internet]. 2015;10(5):1-12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25970536/
-53. Schmulson M, Balbuena R, Corona de Law C. Experiencia clínica con el uso de los anticuerpos anti-CdtB y anti-vinculina en pacientes con diarrea en México. Rev Gastroenterol Mex [Internet]. 2016;81(4):236-9. Disponible en: http://dx.doi.org/10.1016/j.rgmx.2016.07.001
-54. Carmona-Sánchez R, Icaza-Chávez ME, Bielsa-Fernández M V, Gómez-Escudero O, Bosques-Padilla F, Coss-Adame E, et al. Consenso mexicano sobre el síndrome de intestino irritable. Revista de Gastroenterologia de Mexico. Elsevier Doyma. 2016;81:149-67.
-55. Rezaie A, Buresi M, Lembo A, Lin H, McCallum R, Rao S, et al. Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus. Am J Gastroenterol [Internet]. 2017;112(5):775-84. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28323273/
-56. Rezaie A, Heimanson Z, McCallum R, Pimentel M. Lactulose breath testing as a predictor of response to rifaximin in patients with irritable bowel syndrome with diarrhea. Am J Gastroenterol [Internet]. 2019;114(12):1886-93. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31688023/
-57. Kavanagh RG, O’Grady J, Carey BW, O’Connor OJ, Maher MM. Review of the role of abdominal imaging in irritable bowel syndrome. World J Radiol [Internet]. 2018;10(11):143-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288676/
-58. Ford AC, Sperber AD, Corsetti M, Camilleri M. Irritable bowel syndrome. Lancet [Internet]. 2020;396(10263):1675-88. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33049223/
-59. Camilleri M. Diagnosis and Treatment of Irritable Bowel Syndrome: A Review [Internet]. JAMA. 2021;325:865-77. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33651094/
-60. Alvarado J, Otero W, Jaramillo S. Guía de práctica clínica para el diagnóstico y tratamiento del síndrome de intestino irritable en población adulta. Rev Colomb Gastroenterol [Internet]. 2015;30(1):43-56. Disponible en: https://www.gastrocol.com/wp-content/uploads/2020/04/5-intestino-irritable_FINAL.pdf
-61. Vasant DH, Paine PA, Black CJ, Houghton LA, Everitt HA, Corsetti M, et al. British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut [Internet]. 2021;70(7):1-27. Disponible en: https://gut.bmj.com/content/70/7/1214
-62. Narula N, Ulic D, Al-Dabbagh R, Ibrahim A, Mansour M, Balion C, et al. Fecal occult blood testing as a diagnostic test in symptomatic patients is not useful: A retrospective chart review. Can J Gastroenterol Hepatol [Internet]. 2014;28(8):421-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25014182/
-63. Fu Y, Wang L, Xie C, Zou K, Tu L, Yan W, et al. Comparison of non-invasive biomarkers faecal BAFF, calprotectin and FOBT in discriminating IBS from IBD and evaluation of intestinal inflammation. Sci Rep [Internet]. 2017;7(1):2669. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453945/
-64. Casellas F, Burgos R, Marcos A, Santos J, Ciriza-De-Los-Ríos C, García-Manzanares Á, et al. Consensus document on exclusion diets in irritable bowel syndrome (IBS). Rev Esp Enfermedades Dig [Internet]. 2018;110(12):806-22. Disponible en: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082018001200009&lng=es&nrm=iso&tlng=es
-65. Van Lanen AS, de Bree A, Greyling A. Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis. Eur J Nutr [Internet]. 2021;60(6):3505-22. Disponible en: https://pubmed.ncbi. nlm.nih.gov/33585949/
-66. Paduano D, Cingolani A, Tanda E, Usai P. Effect of three diets (low-FODMAP, gluten-free and balanced) on irritable bowel syndrome symptoms and health-related quality of life. Nutrients [Internet]. 2019;11(7):1566. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31336747/
-67. Marsh A, Eslick EM, Eslick GD. Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis. Eur J Nutr [Internet]. 2016;55(3):897-906. Disponible en: https://link.springer.com/article/10.1007/s00394-015-0922-1
-68. Dionne J, Ford AC, Yuan Y, Chey WD, Lacy BE, Saito YA, et al. A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPs Diet in Treating Symptoms of Irritable Bowel Syndrome [Internet]. Am J Gastroenterol. 2018;113:1290-300. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30046155/
-69. Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology [Internet]. 2013;145(2):320-8.e1. Disponible en: https://europepmc.org/article/med/23648697
-70. Johannesson E, Simrén M, Strid H, Bajor A, Sadik R. Physical activity improves symptoms in irritable bowel syndrome: A randomized controlled trial. Am J Gastroenterol [Internet]. 2011;106(5):915-22. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21206488/
-71. Johannesson E, Ringstrom G, Abrahamsson H, Sadik R. Intervention to increase physical activity in irritable bowel syndrome shows long-term positive effects. World J Gastroenterol [Internet]. 2015;21(2):600-8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25593485/
-72. Hamaguchi T, Tayama J, Suzuki M, Nakaya N, Takizawa H, Koizumi K, et al. The effects of locomotor activity on gastrointestinal symptoms of irritable bowel syndrome among younger people: An observational study. PLoS One [Internet]. 2020;15(5). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32470098/
-73. Schumann D, Anheyer D, Lauche R, Dobos G, Langhorst J, Cramer H. Effect of Yoga in the Therapy of Irritable Bowel Syndrome: A Systematic Review [Internet]. Clin Gastroenterol Hepatol. 2016;14:1720-31. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27112106/
-74. Di Palma JA, Herrera JL. The role of effective clinician-patient communication in the management of irritable bowel syndrome and chronic constipation [Internet]. J Clin Gastroenterol. 2012;46:748-51. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22810107/
-75. Hulme K, Chilcot J, Smith M. Doctor-patient relationship and quality of life in Irritable Bowel Syndrome: an exploratory study of the potential mediating role of illness perceptions and acceptance. Psychol Health Med [Internet]. 2018;23(6):674-84. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29260889/
-76. Schmulson MJ, Ortiz-Garrido OM, Hinojosa C, Arcila D. A single session of reassurance can acutely improve the self-perception of impairment in patients with IBS. J Psychosom Res [Internet]. 2006;61(4):461-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17011353/
-77. Remes-Troche J, Gómez-Escudero O, Rojas b JN, Carmona-Sánchez R, Pérez-Manautae J, López-Colombo A, et al. Tratamiento farmacológico del síndrome de intestino irritable: revisión técnica. Rev Gastroenterol México [Internet]. 2010;75(1):42-66. Disponible en: http://www.revistagastroenterologiamexico.org/es-tratamiento-farmacologico-del-sindrome-intestino-articulo-resumen-X0375090610498417
-78. Ruepert L, Quartero AO, de Wit NJ, van der Heijden GJ, Rubin G, Muris JW. Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome [Internet]. Cochrane Database Syst Rev. 2011Disponible en: https://pubmed.ncbi.nlm.nih.gov/21833945/
-79. Costa Barney VA, Ovalle Hernández AF. Rol de los antiespasmódicos en el manejo del síndrome de intestino irritable [Internet]. Revista Colombiana de Gastroenterologia. 2019;34:269-76. Disponible en: https://doi.org/10.22516/25007440.309
-80. Martínez-Vázquez MA, Vázquez-Elizondo G, González-González JA, Gutiérrez-Udave R, Maldonado-Garza HJ, Bosques-Padilla FJ. Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: Systematic review and meta-analysis [Internet]. Rev Gastroenterol Mex. 2012;77:82-90. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22672854/
-81. Bustos-Fernández LM, Hanna-Jairala I. Tratamiento actual del síndrome de intestino irritable. Una nueva visión basada en la experiencia y la evidencia. Acta Gastroenterol Latinoam [Internet]. 2019;49(4):381-93. Disponible en: https://actagastro.org/tratamientoactual-del-sindrome-de-intestino-irritable-una-nueva-vision-basadaen-la-experiencia-y-la-evidencia/
-82. Rzetelna H, Porto Alegre Rosa CF, Kirzner M, de Medeiros LPJ, Melo C, Ribeiro MG, et al. Clinical Assessment of the Use of Propinox Hydrochloride and Scopolamine Hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study. Int J Clin Med [Internet]. 2016;07(07):474-80. Disponible en: https://www.scirp.org/journal/paperinformation.aspx?paperid=68424
-83. Pulpeiro A, Martí ML, De Los Santos AR, Di Girolamo G. Propinox en síndrome de intestine irritable. Prensa Med Argent [Internet]. 2000;87(3):299-307. Disponible en: https://www.researchgate.net/publication/289908528_Propinox_en_sindrome_de_intestine_irritable
-84. Di Girolamo G, De los Santos AR, Martí ML, Valdés Quintana E, Godoy MI, Morano MA, et al. Propinox in intestinal colic: Multicenter randomized prospective double-blind study of three doses of propinox vs. placebo in acute intestinal colic pain. Int J Clin Pharmacol Res [Internet]. 2000;20(1-2):31-40. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11146900/
-85. Castillo R. Propinox mas clonixinato de lisitina por vía oral en dolor cólico abdominal. Prensa méd argent [Internet]. 1997;84(2):126-33. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/lil-225960
-86. Zheng L, Lai Y, Lu W, Li B, Fan H, Yan Z, et al. Pinaverium reduces symptoms of irritable bowel syndrome in a multicenter, randomized, controlled trial. Clin Gastroenterol Hepatol [Internet]. 2015;13(7):1285-1292.e1. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25632806/
-87. Bustos-Fernández LM, Hanna-Jairala I. Tratamiento actual del síndrome de intestino irritable. Una nueva visión basada en la experiencia y la evidencia. Acta Gastroenterol Latinoam [Internet]. 2019;49(4):381-93. Disponible en: https://www.actagastro.org/numeros-anteriores/2019/Vol-49-N4/Vol49N4-PDF17.pdf
-88. Ford AC, Lacy BE, Harris LA, Quigley EMM, Moayyedi P. Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis. Am J Gastroenterol. 2019;114(1):21-39.
-89. García Muñoz E, Licona Galicia DG. Usos potenciales de la mirtazapina en cuidados paliativos más allá de su efecto antidepresivo [Internet]. Revista de la Sociedad Espanola del Dolor. 2018;25:37-44. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1134-80462018000100037&lng=es&nrm=iso&tlng=es
-90. Akama F, Mikami K, Watanabe N, Kimoto K, Yamamoto K, Matsumoto H. Efficacy of mirtazapine on irritable bowel syndrome with anxiety and depression: A case study. J Nippon Med Sch [Internet]. 2018;85(6):330-3. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30568059/
-91. Furnari M, De Bortoli N, Martinucci I, Bodini G, Revelli M, Marabotto E, et al. Optimal management of constipation associated with irritable bowel syndrome [Internet]. Therapeutics and Clinical Risk Management. Dove Press. 2015;11:691-703. Disponible en: https://www.dovepress.com/getfile.php?fileID=24855
-92. Mearin F, Ciriza C, Mínguez M, Rey E, Mascort JJ, Peña E, et al. Guía de Práctica Clínica: síndrome del intestino irritable con estreñimiento y estreñimiento funcional en adultos. Rev Española Enfermedades Dig [Internet]. 2016;108(6):332-63. Disponible en: https://scielo.isciii.es/scielo.php?pid=S1130-01082016000600007&script=sci_arttext&tlng=es
-93. Moayyedi P, Quigley EMM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. The effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysis. [Internet]. Am J Gastroenterol. 2014;109:1367-74. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25070054/
-94. Moayyedi P, Andrews CN, MacQueen G, Korownyk C, Marsiglio M, Graff L, et al. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS). J Can Assoc Gastroenterol [Internet]. 2019;2(1):6-29. Disponible en: https://academic.oup.com/jcag/article/2/1/6/5290372
-95. Ford AC, Moayyedi P, Chey WD, Harris LA, Lacy BE, Saito YA, et al. American college of gastroenterology monograph on management of irritable bowel syndrome. Am J Gastroenterol [Internet]. 2018;113(S2):1-18. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29950604/
-96. Lee-Robichaud H, Thomas K, Morgan J, Nelson RL. Lactulose versus Polyethylene Glycol for Chronic Constipation. Cochrane Database Syst Rev [Internet]. 2010;(7). Disponible en: https://pubmed.ncbi.nlm.nih.gov/20614462/
-97. Chapman RW, Stanghellini V, Geraint M, Halphen M. Randomized clinical trial: Macrogol/PEG 3350 plus electrolytes for treatment of patients with constipation associated with irritable bowel syndrome. Am J Gastroenterol [Internet]. 2013;108(9):1508-15. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23835436/
-98. Wall GC, Bryant GA, Bottenberg MM, Maki ED, Miesner AR. Irritable bowel syndrome: A concise review of current treatment concepts [Internet]. World J Gastroenterol. 2014;20:8796-806. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25083054/
-99. Kamm MA, Mueller-Lissner S, Wald A, Richter E, Swallow R, Gessner U. Oral Bisacodyl Is Effective and Well-Tolerated in Patients With Chronic Constipation. Clin Gastroenterol Hepatol [Internet]. 2011;9(7):577-83. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21440672/
-100. Mueller-Lissner S, Kamm MA, Wald A, Hinkel U, Koehler U, Richter E, et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol [Internet]. 2010;105(4):897-903. Disponible en: https://pubmed.ncbi.nlm.nih.gov/20179697/
-101. Morel Cerda EC, Remes Troche JM. Estreñimiento crónico síndrome de intestino irritable y enfermedad intestinal inflamatoria. En: Valdovinos Díaz MÁ, Coss Adame E, Gómez Escudero O, Yamamoto Furusho JK, editors. Permanyer Mexico [Internet]. México; 2020. Pp. 53-60. Disponible en: https://www.researchgate.net/publication/344371448_Libro_Estrenimiento_cronico_sindrome_de_intestino_irritable_y_enfermedad_inflamatoria_intestinal_Editores_Miguel_A_Valdovinos_Diaz_Enrique_Coss_Adame_Octavio_Gomez_Escudero_Jesus_Kazuo_Yamamoto_Furush
-102. Chey WD, Lembo AJ, Lavins BJ, Shiff SJ, Kurtz CB, Currie MG, et al. Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol [Internet]. 2012;107(11):1702-12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22986437/
-103. Rao S, Lembo AJ, Shiff SJ, Lavins BJ, Currie MG, Jia XD, et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol [Internet]. 2012;107(11):1714-24. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22986440/
-104. Videlock EJ, Cheng V, Cremonini F. Effects of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation: A Meta-analysis [Internet]. Clin Gastroenterol Hepatol. 2013;11:1084-1092.e3. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23644388/
-105. Shah ED, Kim HM, Schoenfeld P. Efficacy and tolerability of guanylate cyclase-C agonists for irritable bowel syndrome with constipation and chronic idiopathic constipation: A systematic review and meta-analysis [Internet]. Am J Gastroenterol. 2018;113:329-38. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29380823/
-106. Drossman DA, Chey WD, Johanson JF, Fass R, Scott C, Panas R, et al. Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome - Results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther [Internet]. 2009;29(3):329-41. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19006537/
-107. Johanson JF, Morton D, Geenen J, Ueno R. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am J Gastroenterol [Internet]. 2008;103(1):170-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17916109/
-108. Johanson JF, Drossman DA, Panas R, Wahle A, Ueno R. Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther [Internet]. 2008;27(8):685-96. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18248656/
-109. Evans B, Clark WK, Moore DJ, Whorwell PJ. Tegaserod for the treatment of irritable bowel syndrome and chronic constipation [Internet]. Cochrane Database Syst Rev. 2007 [citado 3 de agosto de 2021]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17943807/
-110. Ford AC, Brandt LJ, Young C, Chey WD, Foxx-Orenstein AE, Moayyedi P. Efficacy of 5-HT 3 antagonists and 5-HT 4 agonists in irritable bowel syndrome: Systematic review and meta-analysis. Am J Gastroenterol [Internet]. 2009;104(7):1831-43. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19471254/
-111. Ford AC, Moayyedi P, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. American college of gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol [Internet]. 2014;109(Suppl. 1):S2-26. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25091148/
-112. Shin A, Camilleri M, Kolar G, Erwin P, West CP, Murad MH. Systematic review with meta-analysis: Highly selective 5-HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation. Aliment Pharmacol Ther [Internet]. 2014;39(3):239-53. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24308797/
-113. Cann PA, Read NW, Holdsworth CD, Barends D. Role of loperamide and placebo in management of irritable bowel syndrome (IBS). Dig Dis Sci [Internet]. 1984;29(3):239-47. Disponible en: https://pubmed.ncbi.nlm.nih.gov/6365490/
-114. Kane JS, Ford AC. Rifaximin for the treatment of diarrhea-predominant irritable bowel syndrome. Expert Rev Gastroenterol Hepatol [Internet]. 2016;10(4):431-42. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26753693/
-115. Black CJ, Burr NE, Camilleri M, Earnest DL, Quigley EM, Moayyedi P, et al. Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis. Gut [Internet]. 2020;69(1):74-82. Disponible en: https://gut.bmj.com/content/69/1/74
-116. Marzoli GA, Federici M, Mascagni M, Maffei P, Calanni F, Claudio VG. Diferencias farmacocinéticas entre rifaximina alfa y una rifaximina genérica. Med Interna Mex [Internet]. 2019;35(3):370-8. Disponible en: https://www.scielo.org.mx/pdf/mim/v35n3/0186-4866-mim-35-03-370.pdf
-117. Dupont HL. Review article: The antimicrobial effects of rifaximin on the gut microbiota [Internet]. Aliment Pharmacol Ther. 2016;43:3-10. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26618921/
-118. Pimentel M, Chow EJ, Lin HC. Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome. Am J Gastroenterol [Internet]. 2000;95(12):3503-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11151884/
-119. Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, et al. Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation. N Engl J Med [Internet]. 2011;364(1):22-32. Disponible en: https://www.nejm.org/doi/full/10.1056/nejmoa1004409
-120. Lembo A, Pimentel M, Rao SS, Schoenfeld P, Cash B, Weinstock LB, et al. Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterology [Internet]. 2016;151(6):1113-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27528177/
-121. Barkun A, Love J, Gould M, Pluta H, Hillary Steinhart A. Bile acid malabsorption in chronic diarrhea: Pathophysiology and treatment [Internet]. Can J Gastroenterol. 2013;27:653-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24199211/
-122. Slattery SA, Niaz O, Aziz Q, Ford AC, Farmer AD. Systematic review with meta-analysis: The prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea [Internet]. Aliment Pharmacol Ther. 2015;42:3-11. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25913530/
-123. Camilleri M, Acosta A, Busciglio I, Boldingh A, Dyer RB, Zinsmeister AR, et al. Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther [Internet]. 2015;41(5):438-48. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25594801/
-124. Bajor A, Törnblom H, Rudling M, Ung KA, Simrén M. Increased colonic bile acid exposure: A relevant factor for symptoms and treatment in IBS. Gut [Internet]. 2015;64(1):84-92. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24727487/
-125. Ruiz-Campos L, Gisbert JP, Ysamat M, Arau B, Loras C, Esteve M, et al. Systematic review with meta-analysis: the prevalence of bile acid malabsorption and response to colestyramine in patients with chronic watery diarrhoea and previous cholecystectomy. Aliment Pharmacol Ther [Internet]. 2019;49(3):242-50. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30585336/
-126. Zheng Y, Yu T, Tang Y, Xiong W, Shen X, Jiang L, et al. Efficacy and safety of 5-hydroxytryptamine 3 receptor antagonists in irritable bowel syndrome: A systematic review and metaanalysis of randomized controlled trials [Internet]. PLoS One. 2017;12:1-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28291778/
-127. Krause R, Ameen V, Gordon SH, West M, Heath AT, Perschy T, et al. A randomized, double-blind, placebo-controlled study to assess efficacy and safety of 0.5 mg and 1 mg alosetron in women with severe diarrhea-predominant IBS. Am J Gastroenterol [Internet]. 2007;102(8):1709-19. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17509028/
-128. Garsed K, Chernova J, Hastings M, Lam C, Marciani L, Singh G, et al. A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. Gut [Internet]. 2014;63(10):1617-25. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24334242/
-129. Barshop K, Staller K. Eluxadoline in irritable bowel syndrome with diarrhea: rationale, evidence and place in therapy. Ther Adv Chronic Dis [Internet]. 2017;8(11):153-60. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29090081/
-130. Holzer P. Opioid receptors in the gastrointestinal tract [Internet]. Regulatory Peptides. Europe PMC Funders. 2009;155:11-7. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163293/
-131. Lembo AJ, Lacy BE, Zuckerman MJ, Schey R, Dove LS, Andrae DA, et al. Eluxadoline for Irritable Bowel Syndrome with Diarrhea. N Engl J Med [Internet]. 2016;374(3):242-53. Disponible en: http://www.nejm.org/doi/10.1056/NEJMoa1505180
-132. US Food and Drug Administration. Viberzi HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet]. US Food and Drug Administration. 2008 [citado 4 de agosto de 2021]. Disponible en: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206940s006lbl.pdf
-133. Wu IXY, Wong CHL, Ho RST, Cheung WKW, Ford AC, Wu JCY, et al. Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis [Internet]. Therap Adv Gastroenterol. 2019;12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30719074/
-134. Peckham EJ, Cooper K, Roberts ER, Agrawal A, Brabyn S, Tew G. Homeopathy for treatment of irritable bowel syndrome [Internet]. Cochrane Database Syst Rev. 2019 [citado 1 de agosto de2021]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31483486/
-135. Bahrami HR, Hamedi S, Salari R, Noras M. Herbal Medicines for the Management of Irritable Bowel Syndrome: A Systematic Review. Electron physician [Internet]. 2016;8(8):2719-25. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27757180/
-136. Ottillinger B, Storr M, Malfertheiner P, Allescher HD. STW 5 (Iberogast®)-a safe and effective standard in the treatment of functional gastrointestinal disorders. Wiener Medizinische Wochenschrift [Internet]. 2013;163(3-4):65-72. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580135/
-137. Chumpitazi BP, Kearns GL, Shulman RJ. Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders [Internet]. Aliment Pharmacol Ther. 2018;47:738-52. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29372567/
-138. Alammar N, Wang L, Saberi B, Nanavati J, Holtmann G, Shinohara RT, et al. The impact of peppermint oil on the irritable bowel syndrome: A meta-analysis of the pooled clinical data 11 Medical and Health Sciences 1103 Clinical Sciences. BMC Complement Altern Med [Internet]. 2019;19(1). Disponible en: https://pubmed.ncbi.nlm.nih.gov/30654773/
-139. Tan G, Hammond DC, Gurrala J. Hypnosis and irritable bowel syndrome: A review of efficacy and mechanism of action. Am J Clin Hypn [Internet]. 2005;47(3):161-78. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15754863/
-140. Miller V, Carruthers HR, Morris J, Hasan SS, Archbold S, Whorwell PJ. Hypnotherapy for irritable bowel syndrome: An audit of one thousand adult patients. Aliment Pharmacol Ther [Internet]. 2015;41(9):844-55. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25736234/
-141. Pajak R, Lackner J, Kamboj SK. A systematic review of minimal-contact psychological treatments for symptom management in Irritable Bowel Syndrome [Internet]. J Psychosom Res. 2013;75:103-12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23915765/
-142. Black CJ, Thakur ER, Houghton LA, Quigley EMM, Moayyedi P, Ford AC. Efficacy of psychological therapies for irritable bowel syndrome: Systematic review and network meta-analysis. Gut [Internet]. 2020;69(8):1441-51. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32276950/
-143. Gaylord SA, Palsson OS, Garland EL, Faurot KR, Coble RS, Mann JD, et al. Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial. Am J Gastroenterol [Internet]. 2011;106(9):1678-88. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21691341/
-144. Naliboff BD, Smith SR, Serpa JG, Laird KT, Stains J, Connolly LS, et al. Mindfulness-based stress reduction improves irritable bowel syndrome (IBS) symptoms via specific aspects of mindfulness. Neurogastroenterol Motil [Internet]. 2020;32(9):e13828. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32266762/
-145. Shah K, Ramos-Garcia M, Bhavsar J, Lehrer P. Mind-body treatments of irritable bowel syndrome symptoms: An updated meta-analysis. Behav Res Ther [Internet]. 2020;128:103462. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32229334/
-146. Ciacci C, Franceschi F, Purchiaroni F, Capone P, Buccelletti F, Iacomini P, et al. Effect of beta-Glucan, Inositol and digestive enzymes in GI symptoms of patients with IBS. Eur Rev Med Pharmacol Sci [Internet]. 2011;15(6):637-43. Disponible en: https://www.europeanreview.org/article/957
-147. Quigley EMM. Probiotics in Functional Bowel Disorders Getting It Right [Internet]. J Clin Gastroenterol. 2011;45:481-2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21617544/
-148. Shanahan F. Probiotics in Perspective [Internet]. Gastroenterology. 2010;139:1808-12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/20965190/
-149. Jeffery IB, O’Toole PW, Öhman L, Claesson MJ, Deane J, Quigley EMM, et al. An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut [Internet]. 2012;61(7):997-1006. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22180058/
-150. Tap J, Derrien M, Törnblom H, Brazeilles R, Cools-Portier S, Doré J, et al. Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome. Gastroenterology [Internet]. 2017;152(1):111-123.e8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27725146/
-151. Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, et al. Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10. Science (80- ) [Internet]. 2000;289(5483):1352-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/10958782/
-152. Mohamadzadeh M, Pfeiler E, Brown J, Zadeh M, Gramarossa M, Managlia E, et al. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A [Internet]. 2011;108(Suppl 1):4623-30. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21282652/
-153. Whorwell PJ, Altringer L, Morel J, Bond Y, Charbonneau D, O’Mahony L, et al. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol [Internet]. 2006;101(7):1581-90. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16863564/
-154. Li B, Liang L, Deng H, Guo J, Shu H, Zhang L. Efficacy and safety of probiotics in irritable bowel syndrome: A systematic review and meta-analysis. Front Pharmacol. 2020;11:332.
-155. Ducrotté P. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol [Internet]. 2012;18(30):4012. Disponible en: http://www.wjgnet.com/1007-9327/full/v18/i30/4012.htm
-156. Yuan F, Ni H, Asche C V., Kim M, Walayat S, Ren J. Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis. Curr Med Res Opin [Internet]. 2017;33(7):1191-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28166427/
-157. Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol [Internet]. 2020;5(7):658-66. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32277872/
-158. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and bifidobacterium lactis UABla-12 improve abdominal pain severity and symptomology in irritable bowel syndrome: Randomized controlled trial. Nutrients [Internet]. 2020;12(2). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32019158/
-159. Ford AC, Harris LA, Lacy BE, Quigley EMM, Moayyedi P. Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome [Internet]. Aliment Pharmacol Ther. 2018;48:1044-60. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30294792/
-160. Hungin APS, Mulligan C, Pot B, Whorwell P, Agréus L, Fracasso P, et al. Systematic review: Probiotics in the management of lower gastrointestinal symptoms in clinical practice - An evidence-based international guide [Internet]. Aliment Pharmacol Ther. 2013;38:864-86. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23981066/
-161. Iovino P, Bucci C, Tremolaterra F, Santonicola A, Chiarioni G. Bloating and functional gastro-intestinal disorders: Where are we and where are we going? [Internet]. World J Gastroenterol. 2014;20:14407-19. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25339827/
-162. Kim HJ, Vazquez Roque MI, Camilleri M, Stephens D, Burton DD, Baxter K, et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil [Internet]. 2005;17(5):687-96. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16185307/
-163. Ringel-Kulka T, Palsson OS, Maier D, Carroll I, Galanko JA, Leyer G, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: A double-blind study. J Clin Gastroenterol [Internet]. 2011;45(6):518-25. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21436726/
-164. Ford AC, Quigley EMM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol [Internet]. 2014;109(10):1547-62. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25070051/
-165. Pineton de Chambrun G, Neut C, Chau A, Cazaubiel M, Pelerin F, Justen P, et al. A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Dig Liver Dis [Internet]. 2015;47(2):119-24. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25488056/
-166. Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, Cazaubiel M, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United Eur Gastroenterol J [Internet]. 2016;4(3):353-62. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924426/
-167. Mourey F, Decherf A, Jeanne J-F, Clément-Ziza M, Grisoni M-L, Machuron F, et al. Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation. http://www.wjgnet.com/ [Internet]. 2022;28(22):2509-22. Disponible en: https://www.wjgnet.com/1007-9327/full/v28/i22/2509.htm
-168. Sun YY, Li M, Li YY, Li LX, Zhai WZ, Wang P, et al. The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial. Sci Rep [Internet]. 2018;8(1):1-11. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29445178/
-169. Akhondi-Meybodi M, Rahimian M, Salmanroghani H, Amirbeigy M, Baghbanian M, Ghelmani S. Study of the Effect of Probiotic Saccharomyces Boulardii on the Treatment of Irritable Bowel Syndrome. J Biol Today’s World [Internet]. 2014;3(7):152-6. Disponible en: http://www.journalbio.com
-170. Barraza-Ortiz DA, Pérez-López N, Medina-López VM, Minero-Alfaro JI, Zamarripa-Dorsey F, Fernández-Martínez NDC, et al. Combination of a Probiotic and an Antispasmodic Increases Quality of Life and Reduces Symptoms in Patients with Irritable Bowel Syndrome: A Pilot Study. Dig Dis [Internet]. 2021;39(3):294-300. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32810850/
-171. Lorenzo-Zúñiga V, Llop E, Suárez C, Álvarez B, Abreu L, Espadaler J, et al. I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life. World J Gastroenterol [Internet]. 2014;26:8709-16. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25024629/

Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2023 Jorge Antonio Galdámez Estrada, Luis Aguilar Paiz, Gianna Minerva Blanco, Sandra Chaves Monge, León de Mezerville Cantillo, Pablo Navarro Castillo, Isaac Quintero, Eliam del Pilar Rivas Polanco, Marco Antonio Sánchez Hernández, Edder Sandoval, Jorge Suazo Barahona, Edwin Vicente Pérez, Mariel Mejía, Silvia María Portillo, Luis Enrique Jerez González, José María Remes Troche, Max Julio Schmulson Wasserman

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.