Neonatal Cholestasis: A Narrative Review of the Working Group of the Latin American Society of Pediatric Gastroenterology, Hepatology and Nutrition

Authors

  • Marcela Godoy Hospital Clínico San Borja Arriaran. Santiago de Chile. Chile. https://orcid.org/0000-0002-6467-953X
  • Carola López Centro Hospitalario Pereira Rossell. Montevideo. Uruguay. https://orcid.org/0000-0001-6167-0444
  • Felipe Álvarez Chavez Hospital de Pediatría, Centro Médico Nacional de Occidente, IMSS. Guadalajara, Jalisco. México. https://orcid.org/0000-0002-5087-3075
  • Raquel Borges Pinto Hospital da Criança Conceição do Grupo Hospitalar Conceição. Porto Alegre, Rio Grande do Sul. Brasil. https://orcid.org/0000-0002-5521-7528
  • Verónica Botero Osorio Unidad de Trasplantes Fundación Valle de Lili. Cali. Colombia https://orcid.org/0000-0001-8855-075X
  • María Valentina Dolz Aguilar Hospital de Carabineros y Clínica Las Condes. Santiago de Chile. Chile. https://orcid.org/0000-0001-8820-8946
  • Michelle Higuera Hospital San José Infantil. Bogotá. Colombia. https://orcid.org/0000-0002-0876-7885
  • Reynaldo de Jesús Michel Aceves Hospital Central Militar. Ciudad de México. México. https://orcid.org/0000-0002-6614-7529
  • Gloria Rios Marcuello Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana. Universidad del Desarrollo. Santiago de Chile. Chile. https://orcid.org/0000-0002-6108-4784
  • Lorena Rodríguez González Hospital San Juan de Dios y Clínica Alemana de Santiago. Santiago de Chile. Chile https://orcid.org/0000-0001-6125-2920
  • Claudia Rojo Lillo Hospital Regional de Antofagasta y Universidad de Antofagasta. Antofagasta. Chile.
  • Humberto E Soriano Departamento de Gastroenterología y Nutrición Pediátrica. Pontificia Universidad Católica de Chile. Santiago de Chile. Chile.
  • Mirta Ciocca Hospital Alemán. Buenos Aires. Argentina. https://orcid.org/0000-0001-7232-7529

DOI:

https://doi.org/10.52787/agl.v52i3.134

Keywords:

Jaundice, neonatal cholestasis, biliary atresia

Abstract

Neonatal jaundice requires a differential diagnosis between unconjugated or indirect hyperbilirubinemia and direct or conjugated hyperbilirubinemia, characteristic of neonatal cholestasis, which is always pathological. It is recommended in all newborns of 15 days or older with jaundice to perform differential bilirubin to be able to detect it. Cholestasis is defined by direct bilirubin > 1 mg/dl (17 µmol/L) and its estimated frequency during the neonatal period is 1:2,500 live births.
The most frequent etiologies are infectious, genetic/metabolic, obstructive, endocrinological, toxic, immunological. The most common cause is biliary atresia, which is clinically manifested by jaundice and acholia, so in patients with these signs that diagnosis should always be considered as the first option to rule out. An early diagnosis of neonatal cholestasis is essential to optimize management of treatable causes and improve prognosis. Unfortunately, diagnosis is not always early. That is why the Working Group of the Latin American Society of Pediatric Gastroenterology, Hepatology and Nutrition carried out this review of diagnosis, treatment and follow-up of neonatal cholestasis, whose objective is to provide a useful tool that allows early diagnosis and improves the prognosis of children with neonatal cholestasis.

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Published

2022-09-29

How to Cite

Godoy, M., López, C., Álvarez Chavez, F., Borges Pinto, R., Botero Osorio, V., Dolz Aguilar, M. V., Higuera, M., Michel Aceves, R. de J., Rios Marcuello, G., Rodríguez González, L., Rojo Lillo, C., Soriano, H. E., & Ciocca, M. (2022). Neonatal Cholestasis: A Narrative Review of the Working Group of the Latin American Society of Pediatric Gastroenterology, Hepatology and Nutrition. Acta Gastroenterológica Latinoamericana, 52(3), 344–354. https://doi.org/10.52787/agl.v52i3.134

Issue

Vol. 52 No. 3 (2022): Acta Gastroenterológica Latinoamericana

Section

Reviews

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Copyright (c) 2022 Marcela Godoy, Carola López, Felipe Álvarez Chavez, Raquel Borges Pinto, Verónica Botero Osorio, María Valentina Dolz Aguilar, Michelle Higuera, Reynaldo de Jesús Michel Aceves, Gloria Ríos Marcuello, Lorena Rodríguez González, Claudia Rojo Lillo, Humberto E. Soriano, Mirta Ciocca

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