Win Ratio: A Different Way to Analyze Clinical Trials. Its Strengths and Weaknesses
DOI:
https://doi.org/10.52787/agl.v55i1.477Keywords:
Win ratioAbstract
Introduced in 2012, the win ratio is an innovative approach to the analysis of combined endpoints in randomized clinical trials (RCTs). Its key strength is that it recognizes the different clinical importance of the components of a compound and prioritizes them in a clinical hierarchy. This approach also has the ability to incorporate repeat events, hospitalizations, and quantitative outcomes, as well as quality of life scores.
References
- Pocock SJ, Ariti CA, Collier TJ, Wang D. The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities. Eur Heart J. 2012;33(2):176-82.
-Pocock SJ, Gregson J, Collier TJ, Ferreira JP, Stone GW. The win ratio in cardiology trials: lessons learnt, new developments, and wise future use. Eur Heart J. 2024;45(22):4684-99.
- Ferreira JP, Jhund PS, Duarte K, Claggett BL, Solomon SD, Pocock S, et al. Use of the win ratio in cardiovascular trials. JACC Heart Fail. 2020;8(6):441-50.
-Redfors B, Gregson J, Crowley A, McAndrew T, Ben-Yehuda O, Stone GW, et al. The win ratio approach for composite endpoints: practical guidance based on previous experience. Eur Heart J. 2020; 41(46):4391-99.
-Claggett B, Pocock S, Wei LJ, Pfeffer MA, McMurray JJV, Solomon SD. Comparison of time-to-first event and recurrent-event methods in randomized clinical trials. Circulation. 2018;138(6):570-77.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Walter Masson
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
