From Pretest to Clinical Decision: The Value of Risk Reclassification
DOI:
https://doi.org/10.52787/agl.v56i2.664Keywords:
Pretest, risk reclassificationAbstract
In medicine, we are constantly seeking new diagnostic and prognostic tools. As a result, clinical variables, serum biomarkers, imaging techniques, and novel predictive models are continually being incorporated with the aim of improving risk assessment and guiding clinical decision-making for our patients. However, a mere statistical association between a variable and a clinical outcome does not guarantee its usefulness in clinical practice.
When a new marker emerges, its value lies not only in its ability to predict events, but also in whether it provides information capable of modifying a patient's risk estimation in a clinically meaningful way.1 In other words, does it enable better decision-making?
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