Intracholecystic Papillary Neoplasm: Rare Pathology of the Gallbladder. A Diagnostic Challenge
DOI:
https://doi.org/10.52787/agl.v53i1.243Keywords:
Intracholectystic papillary neoplasm, gallbladder tumor, gallbladder polyp, gallbladder, cholecystectomyAbstract
Introduction. Intracholecystic papillary neoplasia is characterized by exophytic growth of the gallbladder epithelium into its interior. Clinical cases. We present two clinical cases with a gallbladder mass that underwent cholecystectomy given the risk of being malignant gallbladder polyps. The pathological anatomy certifies that they correspond to an intracholecystic papillary neoplasia. Discussion. Intracholecystic papillary neoplasia is a rare pathology, whose incidence varies from 0.5 to 0.8%, predominates in females and affects patients with a mean age of 60 years. Macroscopically it appears as a gallbladder polyp. It is a lesion with potential risk of malignancy which is why it is considered a precursor lesion for the development of invasive gallbladder carcinoma. It is important to note that intracholecystic papillary neoplasia that progresses to invasive carcinoma has a better prognosis than gallbladder carcinoma that originates from another type of lesion. Conclusion. The presence of an exophytic growth lesion at the gallbladder level should make us suspect intracholecystic papillary neoplasia, being recommended to perform cholecystectomy.
References
-1. WHO ClassificationofTumours Editorial Board. Digestive systemtumours. Lyon (France): International Agency forResearchonCancer: 2019. (WHO classification of tumours series, 5th ed;vol.1.
-2. Adsay V, Jang K, Roa J, Dursun N, Ohike N, Bagci P. Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥ 1.0 cm): Clinicopathologic and immuno histochemicalanalysisof 123 cases. Am J SurgPathol 2012; 36:1279-301. DOI: 10.1097/PAS.0b013e318262787c
-3. Kiruthiga K, Kodiatte T, Burad D, Kurian R, RavishSanghiRaju, ManbhaLamareRymbai, et al. Intracholecystic papillary-tubular neoplasms of the gallbladder - A clinicopathological study of 36 cases. Annalsof Diagnostic Pathology 2019; 40:88-93. DOI.org/10.1016/j.anndiagpath.2019.04.014
-4. Bennett S, Marginean E, Paquin-Gobeil M, Wasserman J, Weaver J, Mimeault R, et al. Clinical and pathological featuresof intraductal papillary neoplasm of the biliary tract and gallbladder. HPB (Oxford) 2015;17(9):811-8. DOI:org/10.1111/hpb.12460
-5. Michalinos A, Alexandrou P, Papalambros A, Oikonomou D, Sakellariou S, Baliou E.Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst: ¿a link between choledocha cyst and gallbladder cancer? World J Surg Oncol 2016; 14:202. DOI: 10.1186/s12957-016-0962-x
-6. Foster DR, Foster DB. Gall-bladder polyps in Peutz-Jeghers syndrome. Postgrad Med J 1980; 56:373-6. DOI: 10.1136/pgmj.56.655.373
-7. Walsh N, Qizilbash A, Banerjee R, et al. Biliary neoplasia in Gardner’ssyndrome. ArchPatholLabMed 1987; 111:76-7.
-8. Argon, A.; Barbet, F. Y. &Nart, D. The relationship between intracholecystic papillary-tubular neoplasms and invasive carcinoma of the gallbladder. Int. J SurgPathol 2016; 24(6):504-11.
-9. Manterola C, Bellolio E, OtzenT, Duque G. Neoplasia papilar intracolecística. Reporte de un caso y revisión de la evidencia existente. Int J Morphol 2018; 36(4):1485-9. http://dx.doi.org/10.4067/S0717-95022018000401485
-10. Oh CH, Dong SH. Progression to invasive cancer after snare polypectomy of intracholecystic papillary neoplasms during gallbladder stone removal by percutaneous transhepatic choledochoscopy: a case report. BMC Gastroenterol 20202;404:1-7. DOI: 10.1186/s12876-020-01547-x
-11. Logrado A, Constantino J, Daniel C, Pereira J, Carvalho M, Casimir C. Low-Grade Dysplastic Intracholecystic Papillary Neoplasia: A Case Report. Am J Case Rep, 2021; 22: e929788 DOI: 10.12659/AJCR.929788
-12. Lee N, Kim S, Kim T, Kim D, Seo H, Jeon T. Difusion-weighted MRI for differentiation of benign from malignant lesions in the gallbladder. Clin Radiol 2014;69(2):e78-85. DOI: 10.1016/j.crad.2013.09.017
-13. Yokode M, Hanada K, Shimizu A, Minami T, Hirohata R, Abe T. Intracholecystic papillary neoplasm of the gallbladder protruding into the common bile duct: a case report. Mol Clin Oncol 2019;11(5):488–92.
-14. Mizobuchi N, Munechika J, Takeyama N, Ohgiya Y, Ohike N, Abe R et al. Three cases of intracystic papillary neoplasm of gallbladder. AbdomRadiol (NY) 2018;43(7):1535-9. DOI: 10.1007/s00261-018-1595-z
-15. Oba T, Sato N, Tamura T, Komeda M, Adachi Y, Matsuyama A, et al. A case of gallbladder adenocarcinoma arising in association with intracystic papillary neoplasm (ICPN) with abundant mucin production. Clin J Gastroenterol 2021 Feb;14(1):319-24. Epub 2020 Sep 19. DOI: 10.1007/s12328-020-01233-1
-16. SaeiHamedani F, Garcia-Buitrago M. Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder: a short review of literature. ApplImmunohistochem Mol Morphol 2020;28(1):57-61. DOI: 10.1097/PAI.0000000000000711
-17. Goetze T. Gallbladder carcinoma: prognostic factors and therapeutic options. World J Gastroenterol 2015;21(43):12211-7. DOI: 10.3748/wjg. v21.i43.12211.
-18. Klöppel G, Adsay V, Konukiewitz B, Kleeff J, SchlitterA, Esposito I. Precancerous lesions of the biliary tree. BestPract. Res. Clin. Gastroenterol 2013;27(2):285-97. DOI: 10.1016/j.bpg.2013.04.002

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